1，Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle (Fredrick 2016)

2，NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy (Yang, 2016)

3，Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice (Yoshino, 2011)

4，CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

5，Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.Bogan KL, Brenner C Annu Rev Nutr. 2008; 28():115-30.

6，Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

7，Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

8， Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle (Fredrick 2016)

9， Digestion and absorption of NAD by the small intestine of the rat (Henderson, 1983)

10，Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet

11，Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manne

12，The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

13， Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.Cell Metabolism, v.24, no.6, 2016 Dec 13, p.795(12)

14，In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Zhu, X.H., Lu, M., Lee, B.Y., Ugurbil, K., and Chen, W. Proc. Natl. Acad. Sci. USA. 2015; 112: 2876–2881

15，Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging. Stein, L.R. and Imai, S. EMBO J. 2014; 33: 1321–134

16，Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Cantó, C., Sauve, A.A., and Bai, P. Mol. Aspects Med. 2013; 34: 1168–1201

17，New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Gibson, B.A. and Kraus, W.L. Nat. Rev. Mol. Cell Biol. 2012; 13: 411–424

18，Therapeutic applications of PARP inhibitors: anticancer therapy and beyond. Curtin, N.J. and Szabo, C. Mol. Aspects Med. 2013; 34: 1217–1256

19，A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

20，Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A.L., Ortolan, E., Vaisitti, T., and Aydin, S. Physiol. Rev. 2008; 88: 841–886

21，Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. Menzies, K.J., Singh, K., Saleem, A., and Hood, D.A.J. Biol. Chem. 2013; 288: 6968–6979

22，SIRT1 metabolic actions: Integrating recent advances from mouse models. Boutant, M. and Canto, C. Mol. Metab. 2014; 3: 5–18

23，Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Kumar, S. and Lombard, D.B. Antioxid. Redox Signaling. 2015; 22: 1060–1077

24，Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-duced diabetes in mice

25，P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Yin, T.C., Britt, J.K., De Jesús-Cortés, H., Lu, Y., Genova, R.M., Khan, M.Z., Voorhees, J.R., Shao, J., Katzman, A.C., Huntington, P.J. et al. Cell Rep. 2014; 8: 1731–1740

26，Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. De Jesús-Cortés, H., Xu, P., Drawbridge, J., Estill, S.J., Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J. et al. Proc. Natl. Acad. Sci. USA. 2012; 109: 17010–17015

27，Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Tesla, R., Wolf, H.P., Xu, P., Drawbridge, J., Estill, S.J., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran, S. et al. Proc. Natl. Acad. Sci. USA. 2012; 109: 17016–17021

28， NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair Substance with the potential to postpone aging

29，Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J.T. et al. J. Biol. Chem. 2006; 281:21745–21754

30，Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., Wang, J., Sastre, M., Ono, K., Sauve, A.A., and Pasinetti, G.M. Neurobiol. Aging. 2013; 34:1581–1588

31，NAD+ and sirtuins in aging and disease (Imai, 2014)

32，Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (Gomes, Sinclair,2013)

33，un Li, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair.A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science 355：1312,(2017)

34，Mouchiroud L., Houtkooper R.H., Moullan N., et al.. The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154: 430-441 (2013).

35，Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice (Yoshino, 2011)

36， Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide ononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice (Uddin, 2016)

37，Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. van de Weijer, T., Phielix, E., Bilet, L., Williams, E.G., Ropelle, E.R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L.M., Paglialunga, S. et al. Diabetes. 2015; 64: 1193–1201

38，Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway (Wei, 2017)

40， Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease (Yao, 2017)

41，Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and repercussion (Yamamoto, 2014)

42，Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the

heart from ischemia and repercussion

43，Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice (de Picciotto, 2016)

44，Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure (Zhang, 2017)

45， Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a iedreich’s ataxia cardiomyopathy model

46，Samuel W.French. Chronic alcohol binging injures the liver and other organs by reducing NAD⁺ levels equired for sirtuin's deacetylase activity. Experimental and Molecular Pathology 100:303-306(2016)

47，NAMPT-mediated NAD+ biosynthesis is essential for vision in mice (lin, 2016)